The Gunners go to Middlesbrough seventh in the Premier League, ten points behind fourth-placed Manchester City with only two games in hand.
Supporters remain angry that Wenger is set to pen a new two-year deal having presided over the club’s backward momentum.
Star forward Alexis Sanchez is set to quit this summer with just a year left on his contract.
Arsene Wenger responds to Alexis Sanchez contract rumours
Fans vented their fury at Selhurst Park last week, calling for Wenger to go and rounding on the players.
The Arsenal boss has responded by calling on his stars to man up and make amends at the Riverside Stadium tonight.
He said: “The fans want to be behind the team and the way we respond on the football pitch will decide the attitude of the fans.
“The fans love the club. It’s a good period to be united and not divided. Historically Arsenal has been about that.”
Theo Walcott, captain on the night in south London, was criticised for his honest admission that the Palace players showed more desire in their 3-0 win. Defender Hector Bellerin was slammed by the travelling fans as he tried to applaud them afterwards.
Wenger defended the Spanish right-back – who suffered an ankle injury earlier this season – as he urged fans to show unity through one of the toughest periods of his reign.
He said: “One of our values is to be together. There’s no better period off the season than to show it now.
“Hector is a guy who is genuinely Arsenal and wants to do well. He is ready to play with pain and I think it is yes. He has not come back to his level since he has been injured.
“I think [he has been feeling the ankle] for a while yes. It has completely healed. There has been no surgery as he is completely clear. But you get bad habits and you forget that your job first is to defend and win challenges because you protect yourself a little bit.
“Then you realise you have to come back and I think now he is trying to focus on again what is important, to defend well and after he can give us that extra bit that is important as well.
“I agree that for a while he was not the Hector Bellerin we had seen at the start of the season.”
Wenger has expressed concern that Bellerin could be called up for this summer’s Under-21 European Championships with Spain. But admitted he could be powerless to prevent the right-back going.
He said: “It’s not ideal after a long season. He should have a rest and prepare for next season. The Spanish players love to play for their country and I think he will go as he loves to play for Spain.”