The Palace boss was left fuming at a string of challenges on his 24-year-old winger here the Asia Trophy.
De Boer said: “Of course when it’s a fair challenge for me it’s not a problem but for example for Wilf Zaha they were really looking for him, to injure him and we can’t accept that.
“I think if you want to sell the Premier League you have to do the job to avoid these crazy kind of challenges.”
West Brom’s Allan Nyom was booked after 33 minutes after a number of fouls on Zaha. The former Manchester United wideman was also involved in clashes with Baggies stars James McClean and Claudio Jacob.
De Boer added: “I saw some signs of wanting to bring the beauty of the game here and the beauty of the game is not those kind of challenges.
“He’s one if the exciting players of the Premier League. I don’t want to think that he’s out for a couple of weeks or months.
“When its fair, you don’t hear me complain [the player] might be a little bit unlucky. For example, the first challenge I think it was a yellow card and then he knows I can’t do another one.
“Now [it you don’t caution] you give him the permission to do another challenge.
“I think I have to give Wilf a good compliment because he stayed calm and spoke with his feet and he made a big step in that, so compliments to Wilf.
“There were some moments where they really went for the ball. I had a feeling that they were going more for the legs than the ball at that moment. You know it’s hard, but still it’s preseason and every manager wants his players fit to start the league.
“Wilf is a player because of his speed, because of his quality, because of his technical ability sometimes he will look up and go past two or three players.”
Baggies boss Tony Pulis hit back: “I thought it was a very competitive game, a good game. Allan’s a defender who likes defending and sometimes he’s got there as quick as he could – but he wasn’t quick enough. I didn’t think there was any malice in it.”
It is the second time in a week that De Boer has criticised the treatment of Zaha here at the Asia Trophy. On Wednesday night he hit out at what he saw as a crude challenge from Liverpool’s Marko Grujic .
De Boer went on: “Wilf is so fast he will get fouled a lot. He knows he has to accept as a player and I think he did very well against Liverpool.
“He did very well today and if referees are looking closely sometimes he could have had two fouls in his favour more or maybe three. It’s like that, we know that.
Midfielder Luka Milivojevic opened the scoring for Palace with a superb free-kick from 25 yards 11 minutes in. It came after the excellent Wilfred Zaha had been brought down by Craig Dawson.
Bakary Sako added a second two minutes before the break when his shot from outside the box deflected off both Dawson and new boy Ahmed Hegazy to wrong-foot keeper Ben Foster.