Hazard hit the late goal at Stamford Bridge which all but ended Tottenham’s title challenge a year ago.
Costa, despite not scoring for Chelsea since March 6 at West Ham, still has 22 goals in all competitions.
Spurs’ 4-0 win over Bournemouth on Saturday, however, was their seventh in a row to send the north Londoners into the showdown brimming with confidence.
Spurs also ended Chelsea’s 13-match winning streak at White Hart Lane in January.
Vertonghen said: “Chelsea is one of the best teams in the league this season and they played great and Eden is obviously a very special player.
“But we have played against him this season and we have played Chelsea and we won. Obviously we lost in the away game.
“Our first half there was maybe the best of the season. We have nothing to be afraid of. Not here at the Lane. Not at Saturday at Wembley.”