Mendes used to have a growing list of players with the Spanish giants and was also responsible for bringing Jose Mourinho to the Spanish capital.
The Portuguese football agent played a crucial role in seeing the likes of Ricardo Carvalho, Angel Di Maria, Pepe, Fabio Coentrao and James Rodriguez arrive at the La Liga winners.
Mendes has been a busy man once again this summer after overseeing moves for Coentrao to join Sporting Lisbon, Pepe to Besiktas and was part of a major deal this week when Rodriguez joined Bayern Munich on a two-year loan deal.
The departure of those three big names means Ronaldo is the sole survivor of Mendes former empire at the Bernabeu.
The Madrid superstar will be upset to see two of his close friends leave in Pepe and Coentrao as he prepares to make a big decision himself over his future in Spain.
The former Manchester United forward is currently away on his summer holiday and will miss the start of pre-season following his participation in the Confederations Cup for Portugal.
But despite revelations earlier in the summer that Ronaldo would quit Spain after he was accused of tax evasion, reports in Spain are now suggesting he will remain with the Champions League winners.