The World Athletics Championships are taking place in Stratford between August 4-13 and the Stadium operators need a period of time to covert it back to football mode.
The Premier League have already been made aware of the request and the Hammers are hopeful that Southampton will stage the game at St Mary’s Stadium on August 19.
If the Saints agree, Slaven Bilic will face the prospect of seeing his side play their first three games of the season away from home.
West Ham were not handed the best of starts with their first game of the season against Europa League champions Manchester United at Old Trafford on August 12.
The second game which was scheduled to be at home against Southampton is set to be switched so the Hammers face the journey down to the south coast.
And their third game of the season is the long trip up to Newcastle on August 26 so the Hammers will certainly be clocking up the miles in the early part of the campaign.
West Ham issued a statement which said: “Our opening fixtures in August will be played away from home as London Stadium welcomes the 2017 IAAF World Athletics Championships for a once-in-a-generation occasion.
“Supporters are therefore advised that our second fixture of the campaign, against Southampton, will be rescheduled, with further details to follow.”
West Ham fans will have to wait until Saturday September 9 before they finally play their first home game when newly promoted Huddersfield are the first visitors to London Stadium.